Role of the 5HT2c receptor in regulation ofmetabolism and mesolimbic dopamine
Neuroscience Graduate Program, Vanderbilt University School of Medicine, U1205 Medical Center North, Nashville, TN 37232, USA.
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Abstract | Serotonin (5HT) in the CNS plays an important role in regulation of behavioraland motivational states, and has an implied role in a number of behavioralpathologies including depression, schizophrenia, and drug abuse. 5HT acts inthe CNS by binding receptors on the surface of neurons which then facilitatemodulation of cellular processes and neuronal activity. The 5HT2c receptoris a G-protein coupled receptor (GPCR) primarilyexpressed in the central nervous system. The 5HT2c receptor is theonly known GPCR subject to a form of post transcriptional modification known asRNA editing, a process in which specific adenosine residues are converted toinosine resulting in functional recoding of the mRNA. Editing of 5HT2c receptortranscripts alters the functional signaling characteristics of the receptor,thus modulating the role the receptor plays in various neural processes. Thisreview discusses evidence for the role of the 5HT2c receptor inregulating feeding behavior, and mesoaccumbal dopamine signaling. Furthermore,it addresses the possible implications of dynamic RNA editing in theseprocesses and discusses approaches to better understand the relationship betweenRNA editing and receptor function in vivo.