Candidate Review:

The Spinal Neuropeptide Y System is a Potential Target for Chronic Pain Therapeutics

Laurie L. Lemons* and Ronald G. Wiley§§

*Neuroscience Graduate Program, Vanderbilt University Medical School, U1205 Medical Center North, Nashville, TN 37232, USA.
§Department of Neurology, Vanderbilt University, Nashville, TN 37232, USA.
Correspondence to L.L. e-mail: laurie.l.lemons@vanderbilt.edu

Abstract | Full Text | PDF

ABSTRACT | Millions of people are affected by chronic pain—pain that persists for weeks, months, and even years. Chronic pain costs the economy billions of dollars in health care and disability and the effected individuals lose sleep, money and time from their lives due to their suffering. There are not any successful, long-term treatments for chronic pain, and development of new medications is hindered unfortunately because the precise organization and function of the neural mechanisms underlying nociception are still unclear. For these reasons, it is important to study the nociceptive pathway to learn the identity and function of neurons and transmitters involved, with the goal of identifying new targets for pain therapeutics.